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Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis.

AbstractINTRODUCTION:
Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).
METHODS:
In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.
RESULTS:
The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.
CONCLUSIONS:
We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.
TRIAL REGISTRATION:
Clinicaltrials.gov NCT01501019. Registered November 29, 2011.
AuthorsMelina Andrade Mattar, Bruno Gualano, Luiz Augusto Perandini, Samuel Katsuyuki Shinjo, Fernanda Rodrigues Lima, Ana Lúcia Sá-Pinto, Hamilton Roschel
JournalArthritis research & therapy (Arthritis Res Ther) Vol. 16 Issue 5 Pg. 473 (Oct 25 2014) ISSN: 1478-6362 [Electronic] England
PMID25344395 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Blood Flow Velocity
  • Dermatomyositis (physiopathology, therapy)
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle, Skeletal (blood supply, physiopathology)
  • Polymyositis (physiopathology, therapy)
  • Prospective Studies
  • Quadriceps Muscle (blood supply, physiopathology)
  • Quality of Life
  • Resistance Training (methods)
  • Surveys and Questionnaires
  • Treatment Outcome
  • Visual Analog Scale

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