Abstract | INTRODUCTION: METHODS: In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention. RESULTS: The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters ( creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention. CONCLUSIONS: We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM. TRIAL REGISTRATION: Clinicaltrials.gov NCT01501019. Registered November 29, 2011.
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Authors | Melina Andrade Mattar, Bruno Gualano, Luiz Augusto Perandini, Samuel Katsuyuki Shinjo, Fernanda Rodrigues Lima, Ana Lúcia Sá-Pinto, Hamilton Roschel |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 16
Issue 5
Pg. 473
(Oct 25 2014)
ISSN: 1478-6362 [Electronic] England |
PMID | 25344395
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Blood Flow Velocity
- Dermatomyositis
(physiopathology, therapy)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Muscle Strength
- Muscle, Skeletal
(blood supply, physiopathology)
- Polymyositis
(physiopathology, therapy)
- Prospective Studies
- Quadriceps Muscle
(blood supply, physiopathology)
- Quality of Life
- Resistance Training
(methods)
- Surveys and Questionnaires
- Treatment Outcome
- Visual Analog Scale
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