Abstract | SIGNIFICANCE: RECENT ADVANCES: CRITICAL ISSUES: Neuroprotective strategies that focus solely on blocking mechanisms of glutamate-mediated excitotoxicity have historically failed in clinical trials. That GOT can enable glutamate to assume the role of a survival factor represents a paradigm shift necessary to develop the overall significance of glutamate in stroke biology. FUTURE DIRECTIONS: Ongoing efforts are focused to develop the therapeutic significance of GOT in stroke-affected brain. Small molecules that target induction of GOT expression and activity in the ischemic penumbra are the focus of ongoing studies.
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Authors | Savita Khanna, Zachary Briggs, Cameron Rink |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 22
Issue 2
Pg. 175-86
(Jan 10 2015)
ISSN: 1557-7716 [Electronic] United States |
PMID | 25343301
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Glutamic Acid
- Aspartate Aminotransferases
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Topics |
- Animals
- Aspartate Aminotransferases
(metabolism)
- Citric Acid Cycle
(physiology)
- Glutamic Acid
(metabolism)
- Humans
- Stroke
(enzymology)
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