Bradyarrhythmias secondary to topical levobunolol hydrochloride solution.

Abstract

An 88-year-old man was admitted with fatigue, dizziness, and heart palpitations. Both the electrocardiogram and Holter confirmed the existence of sinus bradycardia and sinus arrest. One hour prior to the onset of symptoms, he received levobunolol hydrochloride solution topically. The levobunolol hydrochloride solution was discontinued and the bradycardia resolved. He was diagnosed as having intermittent sinus bradycardia and sinus arrest, induced by topical β-blocker therapy. Levobunolol hydrochloride solution is an effective therapy for ocular hypertension, probably by reducing aqueous fluid production. However, it can induce cardiac side effects such as bradyarrhythmia and should be used with caution in elderly patients or patients with cardiac disease.

• Authors: Lianjun Lin, Yuchuan Wang, Yan Chen, Meilin Liu
• Journal: Clinical interventions in aging (Clin Interv Aging) Vol. 9 Pg. 1741-5 ( 2014) ISSN: 1178-1998 [Electronic] New Zealand
• PMID: 25342892 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Ophthalmic Solutions
• Levobunolol

Topics

• Adrenergic beta-Antagonists (administration & dosage, adverse effects)
• Aged, 80 and over
• Bradycardia (chemically induced, diagnosis)
• Electrocardiography, Ambulatory (drug effects)
• Heart Rate (drug effects)
• Humans
• Levobunolol (administration & dosage, adverse effects)
• Male
• Ocular Hypertension (drug therapy)
• Ophthalmic Solutions
• Sinus Arrest, Cardiac (chemically induced, diagnosis)