Abstract | BACKGROUND/AIM: The primary role of fine-needle aspiration cytology (FNAC) of salivary gland masses is to determine the underlying process and guide further management. The objective of our study is to provide a comprehensive review of cytologic features and ancillary studies of mammary analog secretory carcinoma (MASC), discuss differential diagnosis and review recent advances in the understanding of its biologic behavior. CASE: A 23-year-old female underwent ultrasound-guided FNA of a slowly enlarging parotid mass. Smears displayed branching clusters of bland vacuolated polygonal cells in a secretory proteinaceous background. Eosinophilic cells with eccentric nuclei and inconspicuous nucleoli were also noted. Based on positive intracellular mucin staining and the lack of extracellular-matrix material, the cytologic diagnosis rendered was 'suspicious for low grade mucoepidermoid carcinoma'. Superficial parotidectomy revealed an MASC confirmed by fluorescence in situ hybridization (FISH) studies for ETV6 translocation. CONCLUSION: MASC should be included in the differential diagnosis of mucinous salivary lesions with cystic changes on FNA. Immunohistochemistry for mammaglobin and S-100 helps in excluding morphologic mimics. FISH helps to confirm the diagnosis. Age alone should not be a deterrent in diagnosing a carcinoma.
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Authors | Jaya Bajaj, Cecilia Gimenez, Farah Slim, Mohamed Aziz, Kasturi Das |
Journal | Acta cytologica
(Acta Cytol)
Vol. 58
Issue 5
Pg. 501-10
( 2014)
ISSN: 0001-5547 [Print] Switzerland |
PMID | 25342157
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2014 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- S100 Proteins
- Secretoglobins
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Topics |
- Biomarkers, Tumor
(genetics)
- Biopsy, Fine-Needle
- Breast Neoplasms
(diagnosis, pathology)
- Carcinoma
(diagnosis, pathology)
- Carcinoma, Acinar Cell
(diagnosis, genetics, pathology)
- Carcinoma, Mucoepidermoid
(diagnosis, pathology)
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Parotid Gland
(metabolism, pathology)
- S100 Proteins
(genetics)
- Salivary Gland Neoplasms
(diagnosis, genetics, pathology)
- Secretoglobins
(genetics)
- Young Adult
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