Thymus in experimental carcinogenesis of the prostate gland.

We studied structural changes in the prostate gland, thymus, and lymph nodes in CBA mice after transplantation of Ehrlich ascites tumor cells into the prostate gland. On experimental day 5, the number of blood and lymph vessels decreased in the gland; the percentage of connective tissue elements and glandular tissue and the number of immunoblasts in the thymus increased. On day 18, the number of blood vessels in the tumor decreased; the width of the cortex and glandular tissue increased in the thymus, while the number of immunoblasts was reduced. On day 28, tumor infiltration and increased number of lymphatic vessels in its stroma were observed; parenchyma was reduced, and the area of the connective tissue increased in the thymus. These structural changes indicated the development of accidental involution of the thymus during carcinogenesis of the prostate.
AuthorsYu I Borodin, A A Lomshakov, V V Astashov, O V Kazakov, A P Mayorov, P M Larionov
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 157 Issue 6 Pg. 724-7 (Oct 2014) ISSN: 1573-8221 [Electronic] United States
PMID25339587 (Publication Type: Comparative Study, Journal Article)
  • Animals
  • Carcinogenesis (metabolism, pathology)
  • Carcinoma, Ehrlich Tumor (blood supply, physiopathology)
  • Connective Tissue (growth & development)
  • Lymph Nodes (physiopathology)
  • Male
  • Mice
  • Mice, Inbred CBA
  • Prostate (physiopathology, secretion)
  • Prostatic Neoplasms (blood supply, physiopathology)
  • Thymus Gland (anatomy & histology, physiopathology)

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