Abstract | PURPOSE: Contrast enhanced ultrasound (CE-US) is a promising imaging modality for non-invasive analysis of functional vascularisation. Lesions of the parotid gland are associated with a vascularisation that differs from normal gland tissue. The aim of this clinical study was to further analyse the perfusion in parotid gland lesions with CE-US. The new quantification software VueBox (Bracco, Italy) was used to assess the perfusion, based on DICOM datasets of CE-US examination. MATERIALS AND METHODS: CE-US measurements were performed by intravenous application of a contrast agent ( SonoVue, Bracco, Italy) before surgical tumor resection. From the analysis of a time sequence of 2D DICOM contrast images, area under time intensity curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in-perfusion-index (WiPI) were calculated using VueBox. These were correlated with the histological analyses of the tumor tissue. RESULTS: Significant difference of area below intensity time curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in perfusion index (WiPI) were observed in the malign lesions compared to benign tumors (p < 0,05) and in pleomorphic adenoma compared to cystadenolymphoma (p < 0,05). CONCLUSION: CE-US seems to be a quantitative and independent method for discriminating between malign and benign parotid gland tumors.
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Authors | Laura V Klotz, Michael Ingrisch, Martin E Eichhorn, Olivier Niemoeller, Vanessa Siedek, Robert Gürkov, Dirk-Andre Clevert |
Journal | Clinical hemorheology and microcirculation
(Clin Hemorheol Microcirc)
Vol. 58
Issue 1
Pg. 261-9
( 2014)
ISSN: 1875-8622 [Electronic] Netherlands |
PMID | 25339101
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Area Under Curve
- Contrast Media
(chemistry)
- Female
- Humans
- Lymphoma
(pathology)
- Male
- Middle Aged
- Parotid Gland
(diagnostic imaging)
- Parotid Neoplasms
(diagnosis, diagnostic imaging, pathology)
- Perfusion
- Reproducibility of Results
- Software
- Ultrasonography
- Young Adult
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