Acute effects of ethanol (0.5 mg/kg) and its interaction with diazepam (5 mg) and meclophenoxate (100 mg) on the blood pressure, the body temperature and the heart rate in man.

Abstract

1. In the course of an experiment in which acute effects of perorally applied ethanol alone (0.5 g/kg of body weight) or in combination with diazepam (5 mg) and meclophenoxate (100 mg) on verbal learning were studied, the values of the blood pressure, the body temperature and the heart rate of experimental subject were simultaneously registered with the help of polyphysiograph Physiomat. 2. The method of artificial conditioned speech connections was adopted. The experimental subjects were 16 healthy and unfatigued volunteers - university students (8 females, 8 males, age 21 years). The investigation-sets consisted of two optic, two complex tactile, and two acoustic associations. Three trials were always carried out: before, and one and two hours after the administration of the studied drugs. 3. The values of the blood pressure, the body temperature and the heart rate were not significantly influenced by the applied substances. Only two hours after application of ethanol in combination with diazepam, a marked decrease of systolic and diastolic blood pressure was registered in comparison with the values observed after application of placebo.

• Authors: J Hrbek, J Macáková, S Komenda, A Siroká, M Rypka
• Journal: Acta Universitatis Palackianae Olomucensis Facultatis Medicae (Acta Univ Palacki Olomuc Fac Med) Vol. 121 Pg. 235-52 ( 1989) ISSN: 0301-2514 [Print] Czech Republic
• PMID: 2533803 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Glycolates
• Ethanol
• Meclofenoxate
• Diazepam

Topics

• Adult
• Blood Pressure (drug effects)
• Body Temperature Regulation (drug effects)
• Diazepam (pharmacology)
• Drug Interactions
• Ethanol (pharmacology)
• Female
• Glycolates (pharmacology)
• Humans
• Male
• Meclofenoxate (pharmacology)