Abstract | UNLABELLED: Patients with sarcoglycanopathies, which comprise four subtypes of autosomal recessive limb-girdle muscular dystrophies, usually present with progressive weakness leading to early loss of ambulation and premature death, and no effective treatment is currently available. OBJECTIVE: METHOD: Patient files were retrospectively analyzed for steroid use. RESULTS: Stabilization of muscle strength was noted in one patient, a slight improvement in two, and a slight worsening in three. In addition, variable responses of forced vital capacity and cardiac function were observed. CONCLUSIONS:
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Authors | Marco A V Albuquerque, Osório Abath-Neto, Jéssica R Maximino, Gerson Chadi, Edmar Zanoteli, Umbertina C Reed |
Journal | Arquivos de neuro-psiquiatria
(Arq Neuropsiquiatr)
Vol. 72
Issue 10
Pg. 768-72
(Oct 2014)
ISSN: 1678-4227 [Electronic] Germany |
PMID | 25337728
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Pregnenediones
- Prednisolone
- deflazacort
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Topics |
- Child
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Male
- Prednisolone
(therapeutic use)
- Pregnenediones
(therapeutic use)
- Retrospective Studies
- Sarcoglycanopathies
(drug therapy)
- Treatment Outcome
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