Plasmonic nanodiamonds: targeted core-shell type nanoparticles for cancer cell thermoablation.

Abstract

Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, core-shell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internalized upon binding to the transferrin receptor. The high plasmonic cross section of the particles in the near-infrared region is utilized to quantitatively ablate the cancer cells with a short, one-minute irradiation by a pulse 750-nm laser.

• Authors: Ivan Rehor, Karin L Lee, Kevin Chen, Miroslav Hajek, Jan Havlik, Jana Lokajova, Milan Masat, Jitka Slegerova, Sourabh Shukla, Hamed Heidari, Sara Bals, Nicole F Steinmetz, Petr Cigler
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 4 Issue 3 Pg. 460-8 (Feb 18 2015) ISSN: 2192-2659 [Electronic] Germany
• PMID: 25336437 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Alexa Fluor 647
• Biocompatible Materials
• Carbocyanines
• Nanodiamonds
• Receptors, Transferrin
• Transferrin
• Polyethylene Glycols
• Gold

Topics

• Ablation Techniques (methods)
• Biocompatible Materials (pharmacokinetics)
• Carbocyanines (chemistry)
• Gold (chemistry)
• HeLa Cells (drug effects)
• Humans
• Hyperthermia, Induced (methods)
• Laser Therapy (methods)
• Molecular Targeted Therapy (methods)
• Nanodiamonds (chemistry)
• Nanoparticles (chemistry)
• Nanoshells (chemistry)
• Polyethylene Glycols (chemistry)
• Receptors, Transferrin (metabolism)
• Transferrin (chemistry, pharmacology)