[Pseudohypobicarbonatemia in a patient with a kappa IgA monoclonal gammapathy].

Abstract

Paraprotein interferences assays are known but rather unusual in clinical chemistry.we here report a paraprotein interference with a bicarbonate assay in a IgA kappa-type myeloma patient. Serum bicarbonate level was assessed by the enzymatic method of a multiparametric chemistry analyzer (Advia 1800, Siemens) as well as a specific electrode assay on a blood gas analyzer (GEM 4000, IL). Paraprotein interference with the enzymatic assay was evidenced by an abnomally low bicarbonate level measured by the enzymatic method in contrast with usual levels obtained by using the gas analyzer and with the clinical status of the patient. Therefore, gammapathy has to be taken into consideration when interpreting biological data.

• Authors: Ismaïl Lazzouni, Emilie Cornec, Ahmed Meskar, Danièle Lucas, Hélène Kerspern, Jean-Luc Carré
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) 2014 Sep-Oct Vol. 72 Issue 5 Pg. 599-601 ISSN: 1950-6112 [Electronic] France
• Vernacular Title: Pseudohypobicarbonatémie chez une patiente atteinte d'une gammapathie monoclonale à IgA kappa.
• PMID: 25336133 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Bicarbonates
• Immunoglobulin A

Topics

• Aged
• Bicarbonates (blood)
• Blood Chemical Analysis
• False Positive Reactions
• Female
• Humans
• Immunoglobulin A
• Paraproteinemias (blood, immunology)
• Water-Electrolyte Imbalance (blood)