[Neuroprotective effect of neuroglutam under conditions of activated free radical oxidation].

Abstract

The neuroprotective properties of the novel glutamic acid derivative neiroglutam have been studied in vitro and in vivo. Neiroglutam demonstrated the protective action on 6-OH-dopamine neurotoxicity model <MI> in vitro, where free radical oxidation is a basic part of pathogenesis. In control rats, focal brain ischemia caused significant increase in thiobarbituric acid reactive species (TBARS) level and decrease in superoxide dismutase (SOD) enzyme activity. In two-year-old rats, preventive administration of the neiroglutam caused a significant reduction in the TBARS plasma concentration (34.5%, p < 0.05), increased SOD activity, and increased the time of acid-induced hemolysis of erythrocytes (40%, p < 0.05).

• Authors: I N Tiurenkov, E V Volotova, D V Kurkin, D A Bakulin, I O Logvinov, T A Antipova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 77 Issue 8 Pg. 16-9 ( 2014) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 25335385 (Publication Type: English Abstract, Journal Article)

Chemical References

• Free Radicals
• Neuroprotective Agents
• Thiobarbituric Acid Reactive Substances
• Glutamic Acid
• Oxidopamine
• Superoxide Dismutase

Topics

• Animals
• Brain Ischemia (drug therapy, metabolism, pathology)
• Cell Line, Tumor
• Erythrocytes (drug effects)
• Free Radicals (antagonists & inhibitors, metabolism)
• Glutamic Acid (analogs & derivatives, pharmacology)
• Hemolysis (drug effects)
• Humans
• Male
• Neurons (cytology, drug effects, metabolism)
• Neuroprotective Agents (pharmacology)
• Oxidation-Reduction
• Oxidative Stress
• Oxidopamine (antagonists & inhibitors, pharmacology)
• Rats
• Superoxide Dismutase (metabolism)
• Thiobarbituric Acid Reactive Substances (analysis)