Clinical aspects of para-tertiary-butylphenolformaldehyde resin (PTBP-FR) allergy.

Abstract

Sensitization by para-tertiary-butylphenolformaldehyde resin (PTBP-FR), which is particularly useful as a leather glue, has been known for 30 years. We retrospectively studied the clinical aspects of those patients with a PTBP-FR allergy among 1966 patients in whom contact dermatitis was confirmed by patch testing. A positive patch test to PTBP-FR was present in 30 patients (1.5%), 24 of whom were women. Exposure to PTBP-FR as a cause of the dermatitis was "certain" in 7, "very likely" in 6 and "unclear" in 17. 67.7% of the patients had a multiple allergy. In 43.3% of the patients, a history of atopy was found. No clear association of PTBP-FR sensitization with allergies to phenolformaldehyde resin (P-FR) or free para-tertiary-butylphenol (PTBP) emerged in this group of 30 patients. This study supports the hypothesis that PTBP-FR and P-FR do not contain the same sensitizers. Follow-up of 26 of the 30 patients showed a favourable course, dependent on identification of the source of exposure, avoidance of further contact and absence of sensitization to multiple allergens.

• Authors: B A Geldof, I D Roesyanto, T van Joost
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 21 Issue 5 Pg. 312-5 (Nov 1989) ISSN: 0105-1873 [Print] England
• PMID: 2533533 (Publication Type: Journal Article)

Chemical References

• Phenols
• Polymers
• Resins, Synthetic
• Formaldehyde
• p-tert-butylphenolformaldehyde resin
• phenol-formaldehyde resin

Topics

• Adolescent
• Adult
• Aged
• Child
• Dermatitis, Atopic (complications)
• Dermatitis, Contact (etiology)
• Dermatitis, Occupational (chemically induced)
• Female
• Follow-Up Studies
• Formaldehyde (adverse effects)
• Humans
• Male
• Middle Aged
• Phenols (adverse effects)
• Polymers (adverse effects)
• Resins, Synthetic (adverse effects)
• Retrospective Studies