Intensification of blood pressure treatment in Pasifika people with type 2 diabetes and renal disease: a cohort study in primary care.

Abstract

BACKGROUND:

Chronic kidney disease is common in Pasifika people with type 2 diabetes. Lowering blood pressure (BP) and reducing proteinuria may slow the rate of progression of renal disease.

METHOD:

We conducted a 2-year study in patients with type 2 diabetes with estimated glomerular filtration rate (eGFR) greater than or equal to 40 ml/mmin/1.73 m² and urinary albumin-creatinine ratio (ACR) greater than or equal to 40 mg/mmol to evaluate a community-based programme aimed at optimising BP. Primary outcomes included BP reduction, remission of albuminuria and change in eGFR.

RESULTS:

Thirty-nine of 47 patients completed greater than or equal to 17 months of intervention. The mean age was 53 plus or minus 8 years; 77% were male. An increase in antihypertensive therapy intensity was accompanied by a median (IQR) reduction in BP of 13[-1.5-22.5)/ 12(1-19) mmHg p<0.05] and urinary ACR (51(20-97) vs. 126(65-194) mg/mmol, p<0.05). Twelve (28%) of 43 patients achieving remission of albuminuria had a faster eGFR loss in the first year compared to the non-remitting group [13.6(4.0-16.6) vs. 3.5(-0.97-7.5) ml/min/1.73 m²/year, (p=0.02), but the rate of loss slowed in the second year. Two patients reached ESRF.

CONCLUISON:

This community-based programme was effective in lowering BP and urinary ACR. In patients who achieved remission of albuminuria, a slower eGFR decline was observed after 12 months.

• Authors: Jasmine Tan, Fifita McCready, Fiona Noovao, Oketi Tepueluelu, John Collins, Tim Cundy
• Journal: The New Zealand medical journal (N Z Med J) Vol. 127 Issue 1404 Pg. 17-26 (Oct 17 2014) ISSN: 1175-8716 [Electronic] New Zealand
• PMID: 25331308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents

Topics

• Adolescent
• Adult
• Aged
• Algorithms
• Antihypertensive Agents (therapeutic use)
• Diabetes Mellitus, Type 2 (complications, ethnology)
• Diabetic Nephropathies (ethnology, etiology)
• Disease Progression
• Female
• Humans
• Hypertension (drug therapy, ethnology)
• Induction Chemotherapy (methods)
• Male
• Middle Aged
• New Zealand
• Primary Health Care
• Prospective Studies
• Risk Factors