Abstract | BACKGROUND: METHODS: The expression of PROK1 protein was assessed in 620 resected sporadic colorectal cancer tissue samples by immunohistochemical staining with in-house-developed human PROK1 mAb to investigate the relationship of PROK1 expression to clinicopathologic factors, recurrence, and survival rate and to evaluate its prognostic significance. RESULTS: The expression of PROK1 protein was detected in 36 % (223/620) of human primary colorectal cancer lesions but no in the healthy mucosa adjacent to the colorectal cancer lesions. According to the clinicopathologic examinations, the frequency of positive PROK1 expression was significantly higher in cases with serosal invasion, lymphatic invasion, venous invasion, lymph node metastasis, liver metastasis, hematogenous metastasis, and higher stage disease. The recurrence rate and prognosis for patients with PROK1 expression-positive lesions were significantly worse. In the Cox proportional hazard model, PROK1 expression was an independent prognostic factor. CONCLUSIONS:
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Authors | Toshiyuki Nakazawa, Takanori Goi, Yasuo Hirono, Akio Yamaguchi |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 22
Issue 5
Pg. 1496-503
(May 2015)
ISSN: 1534-4681 [Electronic] United States |
PMID | 25331005
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Gastrointestinal Hormones
- PROK1 protein, human
- Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
(immunology)
- Biomarkers, Tumor
(metabolism)
- Blotting, Western
- Case-Control Studies
- Colorectal Neoplasms
(metabolism, mortality, pathology)
- Female
- Follow-Up Studies
- Gastrointestinal Hormones
(metabolism)
- Humans
- Immunoenzyme Techniques
- Liver Neoplasms
(metabolism, mortality, secondary)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(metabolism, mortality, pathology)
- Neoplasm Staging
- Neovascularization, Pathologic
- Peritoneal Neoplasms
(metabolism, mortality, secondary)
- Prognosis
- Survival Rate
- Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
(metabolism)
- Young Adult
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