Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients.

Abstract

BACKGROUND:

Longevinex® (L/RV) is a low dose hormetic over-the-counter (OTC) oral resveratrol (RV) based matrix of red wine solids, vitamin D3 and inositol hexaphosphate (IP6) with established bioavailability, safety, and short-term efficacy against the earliest signs of human atherosclerosis, murine cardiac reperfusion injury, clinical retinal neovascularization, and stem cell survival. We previously reported our short-term findings for dry and wet age-related macular degeneration (AMD) patients. Today we report long term (two to three year) clinical efficacy.

METHODS:

We treated three patients including a patient with an AMD treatment resistant variant (polypoidal retinal vasculature disease). We evaluated two clinical measures of ocular structure (fundus autofluorescent imaging and spectral domain optical coherence extended depth choroidal imaging) and qualitatively appraised changes in macular pigment volume. We further evaluated three clinical measures of visual function (Snellen visual acuity, contrast sensitivity, and glare recovery to a cone photo-stress stimulus).

RESULTS:

We observed broad bilateral improvements in ocular structure and function over a long time period, opposite to what might be expected due to aging and the natural progression of the patient's pathophysiology. No side effects were observed.

CONCLUSIONS:

These three cases demonstrate that application of epigenetics has long-term efficacy against AMD retinal disease, when the retinal specialist has exhausted other therapeutic modalities.

• Authors: Stuart Richer, Shana Patel, Shivani Sockanathan, Lawrence J Ulanski 2nd, Luke Miller, Carla Podella
• Journal: Nutrients (Nutrients) Vol. 6 Issue 10 Pg. 4404-20 (Oct 17 2014) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 25329968 (Publication Type: Case Reports, Journal Article)

Chemical References

• Stilbenes
• Resveratrol

Topics

• Aged
• Aged, 80 and over
• Aging (drug effects, pathology)
• Dietary Supplements
• Female
• Humans
• Macular Degeneration (diet therapy, pathology, physiopathology)
• Male
• Middle Aged
• Nutritional Support (methods)
• Resveratrol
• Retina (drug effects, pathology)
• Stilbenes (administration & dosage, pharmacology)
• Time Factors
• Treatment Outcome
• Visual Acuity (drug effects)