[Effect on performance ozonized perftoran cytokine profile in generalized peritonitis].

Abstract

The article analyzes the results of surgical treatment of 78 patients with generalized peritonitis (GP) between the ages of 18 to 76 years. Severity was assessed by RP Mannheim peritoneal index (MPI). The study was conducted according to a comparative evaluation of the method of treatment in both groups. In the comparison group included 38 patients who received conventional therapy without immune complex. In 40 patients of the study group on the background of complex therapeutic measures in pre- and postoperative additionally used concomitant local and systemic ozone therapy (OT) with ozonatedperftoran (OP). All patients in the dynamics of blood prior to surgery, on the 3rd and 7th day after surgery was determined TNF-α, IL-4 and IL-8 by IFA. In general, patients in both groups at admission were identified imbalance between pro- and anti-inflammatory cytokines. Patients of the main group on the complex background of basic therapy combined local and systemic administration of OP positive effect in terms of acceleration available cytokine imbalance. The complex therapeutic interventions GP application of local and systemic OT with OP accelerates elimination of imbalances in the cytokine profile.

• Authors: I A Abdullaev
• Journal: Khirurgiia (Khirurgiia (Mosk)) Issue 9 Pg. 30-2 ( 2014) ISSN: 0023-1207 [Print] Russia (Federation)
• PMID: 25327742 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Substitutes
• Fluorocarbons
• Interleukin-8
• Oxidants, Photochemical
• Tumor Necrosis Factor-alpha
• Interleukin-4
• Ozone
• perftoran

Topics

• Administration, Intravenous
• Adult
• Aged
• Blood Substitutes (administration & dosage)
• Female
• Fluorocarbons (administration & dosage)
• Humans
• Interleukin-4 (blood)
• Interleukin-8 (blood)
• Male
• Middle Aged
• Monitoring, Immunologic
• Oxidants, Photochemical (administration & dosage, pharmacology)
• Ozone (administration & dosage, pharmacology)
• Perioperative Care (methods)
• Peritoneal Lavage (methods)
• Peritonitis (drug therapy, immunology, physiopathology, surgery)
• Severity of Illness Index
• Treatment Outcome
• Tumor Necrosis Factor-alpha (blood)