Abstract | BACKGROUND: METHODS: We analyzed FAK expression by immunohistochemical staining in 196 breast primary tumor samples from stage II-IV patients and in 117 metastatic tissues matched to the primary tumors using TMA that were stained with FAK monoclonal antibody. RESULTS: High FAK expression in primary tumors was associated with a younger age of patients (p = 0.033), lymphovascular invasion (p = 0.001) and with the triple-negative phenotype (p = 0.033). FAK expression in 117 metastatic tissues positively correlated with FAK expression in matched primary tumors by Spearman correlation analysis. In addition, a strong positive correlation was observed between high FAK expression and shorter overall survival and progression free survival in patients with metastatic tumors. CONCLUSIONS: The data demonstrate a high potential for FAK as a therapeutic target, especially in triple-negative breast cancer patients with high FAK expression.
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Authors | Vita M Golubovskaya, Lourdes Ylagan, Austin Miller, Melissa Hughes, Jason Wilson, David Wang, Elizabeth Brese, Wiam Bshara, Stephen Edge, Carl Morrison, William G Cance |
Journal | BMC cancer
(BMC Cancer)
Vol. 14
Pg. 769
(Oct 17 2014)
ISSN: 1471-2407 [Electronic] England |
PMID | 25326692
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Focal Adhesion Protein-Tyrosine Kinases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(genetics, pathology)
- Female
- Focal Adhesion Protein-Tyrosine Kinases
(genetics, metabolism)
- Gene Expression
- Humans
- Immunohistochemistry
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Neovascularization, Pathologic
(genetics, metabolism)
- Triple Negative Breast Neoplasms
(genetics, pathology)
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