Abstract | BACKGROUND:
Immunoglobulin γ marker (GM) and κ marker ( KM) allotypes, hereditary antigenic determinants of γ and κ chains, respectively, have been shown to be associated with immunity to a variety of self and nonself antigens, but their possible contribution to immunity to the tumor-associated antigens epidermal growth factor receptor (EGFR) and EGFR variant (v)III has not been evaluated. The aim of the present investigation was to determine whether the interindividual variation in endogenous antibody responsiveness to EGFR and EGFRvIII is associated with particular GM, KM, and Fcγ receptor (FcγR) genotypes and whether antibody levels were associated with the overall survival of patients with glioblastoma. METHODS: RESULTS: The anti-EGFR antibody levels associated with GM 3/3 homozygotes and GM 3/17 heterozygotes were similar (15.9 vs 16.4 arbitrary units [AU]/µL) and significantly lower than those associated with GM 17/17 homozygotes (19.6 AU/µL; nominal P = .007). Participants homozygous for the GM 21 allele also had significantly higher levels of anti-EGFR antibodies than GM 5/5 homozygotes and GM 5/21 heterozygotes (20.1 vs 16.0 and 16.3 AU/µL; nominal P = .005). Similar associations were found with immune responsiveness to EGFRvIII. Higher anti-EGFR and anti- EGFRvIII antibody levels were associated with enhanced overall survival (16 vs 11 mo, nominal P = .038 and 20 vs 11 mo, nominal P = .004, respectively). CONCLUSIONS:
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Authors | Janardan P Pandey, Emily Kistner-Griffin, Faisal F Radwan, Navtej Kaur, Aryan M Namboodiri, Laurel Black, Mary Ann Butler, Tania Carreon, Avima M Ruder |
Journal | Neuro-oncology
(Neuro Oncol)
Vol. 17
Issue 5
Pg. 678-84
(May 2015)
ISSN: 1523-5866 [Electronic] England |
PMID | 25326496
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Copyright | © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- Immunoglobulin Gm Allotypes
- Immunoglobulin Km Allotypes
- Receptors, IgG
- ErbB Receptors
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Topics |
- Adolescent
- Adult
- Aged
- ErbB Receptors
(immunology)
- Female
- Genotype
- Glioblastoma
(genetics, immunology, mortality)
- Humans
- Immunoglobulin Gm Allotypes
(genetics, immunology)
- Immunoglobulin Km Allotypes
(genetics, immunology)
- Male
- Middle Aged
- Receptors, IgG
(genetics)
- Survival
- Young Adult
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