Synthesis and biomedical applications of xylosides.

Abstract

Xylosides modulate the biosynthesis of sulfated glycosaminoglycans (GAGs) in various cell types. A new class of xylosides called "click-xylosides" has been synthesized for their biostability, ease of chemical synthesis, and tunable sulfated GAG biogenesis in vitro and in vivo. These click-xylosides have several therapeutic and biomedical applications in the regulation of angiogenesis, tumor inhibition, and regeneration. This protocol focuses on the synthesis of click-xylosides, their cellular priming activities, and biomedical applications.

• Authors: Mausam Kalita, Maritza V Quintero, Karthik Raman, Vy M Tran, Balagurunathan Kuberan
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 1229 Pg. 517-28 ( 2015) ISSN: 1940-6029 [Electronic] United States
• PMID: 25325977 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Glycosaminoglycans
• Glycosides
• xylosides

Topics

• Acetylation
• Animals
• Biomedical Technology (methods)
• CHO Cells
• Cattle
• Click Chemistry
• Cricetinae
• Cricetulus
• Glycosaminoglycans (chemistry, metabolism)
• Glycosides (biosynthesis, chemistry)
• Neovascularization, Physiologic