Abstract |
Xylosides modulate the biosynthesis of sulfated glycosaminoglycans (GAGs) in various cell types. A new class of xylosides called "click- xylosides" has been synthesized for their biostability, ease of chemical synthesis, and tunable sulfated GAG biogenesis in vitro and in vivo. These click- xylosides have several therapeutic and biomedical applications in the regulation of angiogenesis, tumor inhibition, and regeneration. This protocol focuses on the synthesis of click- xylosides, their cellular priming activities, and biomedical applications.
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Authors | Mausam Kalita, Maritza V Quintero, Karthik Raman, Vy M Tran, Balagurunathan Kuberan |
Journal | Methods in molecular biology (Clifton, N.J.)
(Methods Mol Biol)
Vol. 1229
Pg. 517-28
( 2015)
ISSN: 1940-6029 [Electronic] United States |
PMID | 25325977
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Glycosaminoglycans
- Glycosides
- xylosides
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Topics |
- Acetylation
- Animals
- Biomedical Technology
(methods)
- CHO Cells
- Cattle
- Click Chemistry
- Cricetinae
- Cricetulus
- Glycosaminoglycans
(chemistry, metabolism)
- Glycosides
(biosynthesis, chemistry)
- Neovascularization, Physiologic
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