Abstract |
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid ( aspirin) is reported to stimulate the synthesis of renal (r)- cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 ( dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)- cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.
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Authors | Rajeshwary Ghosh, Sarbashri Bank, Uttam K Maji, Rabindra Bhattacharya, Santanu Guha, Nighat N Khan, A Kumar Sinha |
Journal | International journal of biomedical science : IJBS
(Int J Biomed Sci)
Vol. 10
Issue 3
Pg. 158-66
(Sep 2014)
ISSN: 1550-9702 [Print] United States |
PMID | 25324696
(Publication Type: Journal Article)
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