Monitoring propranolol treatment in periocular infantile haemangioma.

Abstract

OBJECTIVE:

To develop a tool for assessing amblyopic risk and monitoring the treatment effect of propranolol in periocular haemangioma management.

METHODS:

We present a study of nine children with periocular haemangioma who underwent propranolol treatment at York Hospital between 2009 and 2013.A proposed measure of amblyogenic risk based on the induced anisometropia resulting from a periocular haemangioma was calculated in the form of a single quantitative value, measured in dioptres. This calculation used published work and developed it to produce a new function, termed the delta defocus equivalent (DFE-∂).Refraction measurements were retrospectively collected from patients' notes in order to measure the trend of DFE-∂ over the treatment period with propranolol.

RESULTS:

The average DFE-∂ at commencement of propranolol was 1.54 (±0.62) D. The average at the end of treatment was 0.39 (±0.38) D.

CONCLUSION:

This work presents a possible tool for assessing amblyopic risk in cases of periocular infantile haemangioma. The DFE-∂ gives a measure in dioptres, which may represent the true amblyopic risk, and so be useful in supporting treatment decisions in paediatric ophthalmology.

• Authors: R Burne, R Taylor, Medscape
• Journal: Eye (London, England) (Eye (Lond)) Vol. 28 Issue 11 Pg. 1281-4; quiz 1285 (Nov 2014) ISSN: 1476-5454 [Electronic] England
• PMID: 25323853 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Propranolol

Topics

• Administration, Oral
• Adolescent
• Adrenergic beta-Antagonists (therapeutic use)
• Amblyopia (diagnosis, etiology)
• Child
• Child, Preschool
• Drug Monitoring
• Eyelid Neoplasms (drug therapy)
• Female
• Hemangioma (drug therapy)
• Humans
• Infant
• Male
• Orbital Neoplasms (drug therapy)
• Propranolol (therapeutic use)
• Refraction, Ocular (physiology)
• Retrospective Studies
• Risk Assessment
• Visual Acuity (physiology)
• Young Adult