Clinical utility of the normalized apparent diffusion coefficient for preoperative evaluation of the aggressiveness of prostate cancer.
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| Abstract | PURPOSE: Normalization of the apparent diffusion coefficient (ADC) may overcome ADC variability attributable to different patient and/or technical factors. The purpose of this study was to compare the efficacy of ADC and the normalized ADC (nADC) for differentiating between prostate cancer with a Gleason score (GS) = 6 and GS > 6 and to identify an optimum reference for nADC calculations. MATERIALS AND METHODS: Our study population comprised 58 patients who underwent diffusion-weighted MRI followed by radical prostatectomy. The nADC of the prostate cancer was calculated as ADC (cancer)/ADC (reference) by using the obturator internus muscle, urine in the bladder, and a 20-ml saline bottle placed on the groin as references. We performed receiver operating characteristic (ROC) analysis to identify the optimum reference for nADC calculations. RESULTS: To differentiate between GS = 6 and GS > 6 prostate cancer, the area under the ROC curve of the nADC obtained with a saline bottle as reference was best (0.85) and significantly better than the area under the ADC ROC curve (0.71). CONCLUSIONS:
nADC is superior to ADC for estimating the aggressiveness of prostate cancer. It is a noninvasive technique that aids in the selection of appropriate treatments.
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| Authors | Ryo Itatani, Tomohiro Namimoto, Akira Yoshimura, Kazuhiro Katahira, Seiichiro Noda, Nobuyuki Toyonari, Kosuke Kitani, Yasuyuki Hamada, Mitsuhiko Kitaoka, Yasuyuki Yamashita |
| Journal | Japanese journal of radiology (Jpn J Radiol) Vol. 32 Issue 12 Pg. 685-91 (Dec 2014) ISSN: 1867-108X [Electronic] Japan |
| PMID | 25323833 (Publication Type: Journal Article) |
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