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Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo.

Abstract
In the present study, the effects of δ-tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of α-tocopherol (α-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with δ-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of α-T were modest. The strong effects of δ-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that δ-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of α-T. Moreover, δ-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified δ-T as a better form of vitamin E than α-T for future clinical studies of prostate cancer prevention.
AuthorsHuarong Huang, Yan He, Xiao-Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du, Dongli Li, Kun Zhang, Ah-Ng Tony Kong, Robert S DiPaola, Chung S Yang, Allan H Conney, Xi Zheng
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 62 Issue 44 Pg. 10752-8 (Nov 05 2014) ISSN: 1520-5118 [Electronic] United States
PMID25322450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Androgen
  • Prostate-Specific Antigen
  • delta-tocopherol
  • Tocopherols
Topics
  • Animals
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Humans
  • Male
  • Mice, SCID
  • Prostate-Specific Antigen (metabolism)
  • Prostatic Neoplasms (drug therapy, metabolism, physiopathology)
  • Receptors, Androgen (metabolism)
  • Tocopherols (administration & dosage)
  • Xenograft Model Antitumor Assays

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