Lichenoid drug eruptions due to nandrolone furylpropionate (Demelon).

Abstract

A case of lichenoid drug eruption due to nandrolone furylpropionate (Demelon) is reported. A 71-year-old man with aplastic anemia developed widespread erythema and reticulation with violaceous papules and pigmentation after receiving intramuscular injections of Demelon weekly for 2 months. The eruption gradually resolved after drug withdrawal, leaving reticular pigmentation. A biopsy specimen of the skin lesion showed lichenoid-type reactions including hydropic or colloid degeneration of the basal cells, sometimes with satellite necrosis, and a band-like subepidermal lymphocytic infiltrate. Most of the mononuclear cells stained strongly for helper/inducer T lymphocytes (Leu 3a).

• Authors: M Aihara, K Kitamura, Z Ikezawa
• Journal: The Journal of dermatology (J Dermatol) Vol. 16 Issue 4 Pg. 330-4 (Aug 1989) ISSN: 0385-2407 [Print] England
• PMID: 2532222 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nandrolone
• nandrolone furylpropionate

Topics

• Aged
• Drug Eruptions (pathology)
• Humans
• Male
• Nandrolone (adverse effects, analogs & derivatives)