Anti-Müllerian hormone as a marker of premature ovarian aging in autoimmune thyroid disease.

Abstract

There is an increased incidence of autoimmune thyroid disease (AITD) in women with infertility. We hypothesized that serum anti-Müllerian hormone (AMH) levels will be lower in premenopausal women with AITD than controls. We evaluated ovarian reserve in women with AITD (n = 85) and healthy controls (n = 80), all <40 years old. Detailed data on reproductive history were obtained. Gonadotrophins, steroids, AMH, and inhibin B levels were measured during the follicular phase. The number of pregnancies as well as live births was lower in women with AITD (p < 0.01). No difference was observed in terms of FSH, estradiol, and inhibin B. AMH levels were lower in AITD women than in controls (1.16 + 0.17 versus 1.28 + 0.25 ng/ml, mean + SD, p = 0.001). According to the multiple regression analysis, even after age adjustment, AITD was significantly and independently affected AMH levels (t = 2.674, p = 0.008). Women with AITD seem to have a diminished ovarian follicular reserve and measurement of serum AMH level has the potential to be used to predict this comorbidity.

• Authors: Fatma Saglam, Eda Demir Onal, Reyhan Ersoy, Cemile Koca, Merve Ergin, Ozcan Erel, Bekir Cakir
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 31 Issue 2 Pg. 165-8 (Feb 2015) ISSN: 1473-0766 [Electronic] England
• PMID: 25319839 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• inhibin B
• Estradiol
• Inhibins
• Anti-Mullerian Hormone

Topics

• Adult
• Aging (blood)
• Anti-Mullerian Hormone (blood)
• Biomarkers (blood)
• Case-Control Studies
• Estradiol (blood)
• Female
• Humans
• Infertility, Female (blood, complications)
• Inhibins (blood)
• Ovarian Reserve
• Pregnancy
• Primary Ovarian Insufficiency (blood)
• Thyroiditis, Autoimmune (blood, complications)