Myeloid cells' evasion of melanoma immunity.

Abstract

An immune-suppressive role of myeloid-derived suppressor cells (MDSCs) in melanoma has long been speculated, whereas molecular mechanisms underlying this role are not well understood. Here, Chung and colleagues show that dendritic cell-associated, heparan sulfate proteoglycans-dependent integrin ligand (DC-HIL), a cell surface immune-modulatory molecule, is highly expressed on tumor-associated MDSCs. Genetic ablation or antibody blockade of DC-HIL delays the growth of transplantable B16 melanoma in syngeneic mice, which is accompanied by enhanced antitumor T-cell activities. These findings support a role for DC-HIL in immune evasion within the melanoma microenvironment.

• Authors: Jun Wang, Lieping Chen
• Journal: The Journal of investigative dermatology (J Invest Dermatol) Vol. 134 Issue 11 Pg. 2675-2677 (Nov 2014) ISSN: 1523-1747 [Electronic] United States
• PMID: 25318429 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Comment)

Chemical References

• Eye Proteins
• Gpnmb protein, mouse
• Membrane Glycoproteins

Topics

• Animals
• Eye Proteins (metabolism)
• Melanoma (metabolism)
• Membrane Glycoproteins (metabolism)
• Monocytes (cytology)