Abstract | BACKGROUND: METHODS: Pretreatment with nefopam (30 mg/kg) was performed intraperitoneally 30 min prior to an intraperitoneal injection of STZ (60 mg/kg). Mechanical and cold allodynia were tested before, and 1 to 4 weeks after drug administration. Thermal hyperalgesia was also investigated. In addition, the transient receptor potential ankyrin 1 (TRPA1) and TRP melastatin 8 (TRPM8) expression levels in the dorsal root ganglion (DRG) were evaluated. RESULTS: Pretreatment with nefopam significantly inhibited STZ-induced mechanical and cold allodynia, but not thermal hyperalgesia. The STZ injection increased TRPM8, but not TRPA1, expression levels in DRG neurons. Pretreatment with nefopam decreased STZ-induced TRPM8 expression levels in the DRG. CONCLUSIONS: These results demonstrate that a nefopam pretreatment has strong antiallodynic effects on STZ-induced diabetic rats, which may be associated with TRPM8 located in the DRG.
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Authors | Jae Sik Nam, Yu Seon Cheong, Myong Hwan Karm, Ho Soo Ahn, Ji Hoon Sim, Jin Sun Kim, Seong Soo Choi, Jeong Gil Leem |
Journal | The Korean journal of pain
(Korean J Pain)
Vol. 27
Issue 4
Pg. 326-33
(Oct 2014)
ISSN: 2005-9159 [Print] Korea (South) |
PMID | 25317281
(Publication Type: Journal Article)
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