HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Natriuretic effect of atriopeptin III in rats with papillary necrosis.

Abstract
This study compared the effects of atriopeptin III (AP III) on sodium excretion and renal interstitial hydrostatic pressure (RIHP) in control rats and in rats pretreated with 2-bromoethylamine (BEA) to produce papillary necrosis. In control rats, infusion of AP III (100 ng.kg-1.min-1) increased sodium excretion from 2.2 +/- 0.7 to 6.4 +/- 0.9 microeq.min-1.g kidney wt-1 and RIHP from 6.8 +/- 0.7 to 8.7 +/- 0.9 mmHg, whereas glomerular filtration rate and renal blood flow were unaltered. Similar results were obtained in rats pretreated with BEA 48 h before the experiment. In rats studied 6 wk after BEA treatment, the papilla was absent and there was atrophy of juxtamedullary nephrons. AP III did not alter sodium excretion or RIHP in this group of rats. These results indicate that 1) an intact renal papilla and/or juxtamedullary nephron population may be required for the natriuretic effect of AP III; 2) the papillary injury 48 h after BEA is not sufficient to abolish the natriuretic response to AP III; and 3) elevations in RIHP may play a role in the natriuretic response to AP III.
AuthorsJ Garcia-Estañ, K Takezawa, R J Roman
JournalThe American journal of physiology (Am J Physiol) Vol. 257 Issue 5 Pt 2 Pg. F859-65 (Nov 1989) ISSN: 0002-9513 [Print] United States
PMID2531550 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Ethylamines
  • 2-bromoethylamine
  • Furosemide
  • Atrial Natriuretic Factor
  • Acetazolamide
Topics
  • Acetazolamide (pharmacology)
  • Animals
  • Atrial Natriuretic Factor (pharmacology)
  • Ethylamines (pharmacology)
  • Furosemide (pharmacology)
  • Hemodynamics (drug effects)
  • Kidney Cortex (blood supply)
  • Kidney Medulla (blood supply, pathology)
  • Kidney Papillary Necrosis (pathology, urine)
  • Male
  • Natriuresis (drug effects)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: