Abstract | BACKGROUND: Multiple surgical interventions are burden to patients with intermittent exotropia (IXT) due to a high recurrence rate. This study was designed to evaluate the efficacy of botulinum toxin injection in the treatment of intermittent exotropia (IXT). METHOD: A total of 21 patients with IXT, who had a far deviation of less than 40 prism diopters (PD), were enrolled. All cases were followed for at least 6 months with non-surgical management and had decremented fusional control (increasing 3 or more scores in Newcastle Control Score [NCS]). Botulinum toxin was injected (10 units Dysport) to both lateral rectus muscles. Fusional control, sensory and motor status were evaluated at 1 day, 1 week, and 1, 3, and 6 months after injection to compare with the pre-injection values. RESULTS: Fusional control (based on NCS) showed a significant improvement during 6-month follow-up. Mean NCS was 4.4±0.8 SD before botulinum toxin injection and 1.4±0.4 SD after 6 months (p<0.001). Evaluation of sensorial status with Worth Four Dot Test (WFDT) also demonstrated an improvement of fusion (the percentage of patients demonstrating fusion on WFDT were 10.5% before injection and 61.5% after 6 months). The mean far and near deviations decreased during 6 months of follow-up examination. Satisfactory outcome (stable binocular alignment of the eyes to an orthophoria+/-10 PD in primary position) for far distance was achieved in 38.1% at 6 months. The percentage of satisfactory outcome at near was 86% at 6 months follow-up examination. CONCLUSION:
Botulinum toxin injection to lateral rectus muscles seems to be a promising procedure in the management of fusional control, far and near deviations in patients with intermittent exotropia in short time.
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Authors | Mohammad Etezad Razavi, Mohammad Sharifi, Fateme Armanfar |
Journal | Strabismus
(Strabismus)
Vol. 22
Issue 4
Pg. 176-81
(Dec 2014)
ISSN: 1744-5132 [Electronic] England |
PMID | 25313677
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetylcholine Release Inhibitors
- Botulinum Toxins, Type A
- abobotulinumtoxinA
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Topics |
- Acetylcholine Release Inhibitors
(therapeutic use)
- Adolescent
- Botulinum Toxins, Type A
(therapeutic use)
- Child
- Child, Preschool
- Exotropia
(drug therapy, physiopathology)
- Female
- Humans
- Injections, Intramuscular
- Male
- Oculomotor Muscles
(drug effects, physiopathology)
- Prospective Studies
- Treatment Outcome
- Vision, Binocular
(physiology)
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