Abstract | BACKGROUND: METHODS: We profiled miRNAs using RNA isolated from the plasma of participants. The results were validated in 64 MHD patients and 18 healthy controls. RESULTS: Levels of plasma miR-133a decreased in MHD patients with LVH compared with those in healthy controls. Plasma miR-133a concentrations were negatively correlated with LVMI and IVS. After single hemodialytic treatment, plasma miR-133a levels remained unchanged. Cardiac Troponin I and T were not associated with LVMI and IVS. CONCLUSIONS:
|
Authors | Ping Wen, Dan Song, Hong Ye, Xiaochun Wu, Lei Jiang, Bing Tang, Yang Zhou, Li Fang, Hongdi Cao, Weichun He, Yafang Yang, Chunsun Dai, Junwei Yang |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 10
Pg. e103079
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25313674
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- MIRN133 microRNA, human
- MicroRNAs
- Troponin I
- Troponin T
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cardiomegaly
(complications, diagnosis, genetics)
- Female
- Heart Ventricles
(diagnostic imaging)
- Humans
- Kidney Failure, Chronic
(complications, diagnosis)
- Logistic Models
- Magnetic Resonance Imaging
- Male
- MicroRNAs
(blood)
- Middle Aged
- Renal Dialysis
- Troponin I
(metabolism)
- Troponin T
(metabolism)
- Ultrasonography
|