HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet.

AbstractPURPOSE:
It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine.
METHODS:
Male Wistar rats were randomly assigned to four groups of eight animals each and were fed a basal or obesogenic (high in fat and low in fibre) diet that contained either rapeseed oil (Canola) or blackcurrant seed oil. A two-way analysis of variance was then applied to assess the effects of diet and oil and the interaction between them.
RESULTS:
After 8 weeks, the obesogenic dietary regimen increased the body weight, altered the plasma lipid profile and increased the liver fat content and the plasma transaminase activities. In addition, the obesogenic diet decreased bacterial glycolytic activity and short-chain fatty acid formation in the distal intestine. Dietary blackcurrant seed oil improved the lipid metabolism by lowering liver fat accumulation and the plasma triglyceride concentration and atherogenicity as well by increasing the plasma HDL-cholesterol concentration. However, in rats fed an obesogenic diet containing blackcurrant seed oil, the plasma HDL-cholesterol concentration was comparable with both rapeseed oil-containing diets, and a significant elevation of the plasma transaminase activities was noted instead.
CONCLUSIONS:
The obesogenic dietary regimen causes a number of metabolic disorders, including alterations in the hindgut microbial metabolism. Dietary blackcurrant seed oil ameliorates the lipid metabolism; however, the beneficial effect is restricted when it is provided together with the obesogenic diet, and a risk of liver injury may occur.
AuthorsAdam Jurgoński, Bartosz Fotschki, Jerzy Juśkiewicz
JournalEuropean journal of nutrition (Eur J Nutr) Vol. 54 Issue 6 Pg. 991-9 (Sep 2015) ISSN: 1436-6215 [Electronic] Germany
PMID25311060 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholesterol, HDL
  • Fatty Acids, Monounsaturated
  • Fatty Acids, Volatile
  • Linolenic Acids
  • Lipids
  • Plant Oils
  • Rapeseed Oil
  • Triglycerides
  • blackcurrant seed oil
  • Transaminases
Topics
  • Animals
  • Bacteria (metabolism)
  • Body Weight
  • Cholesterol, HDL (blood)
  • Diet
  • Fatty Acids, Monounsaturated
  • Fatty Acids, Volatile (metabolism)
  • Fatty Liver (etiology, metabolism)
  • Glycolysis
  • Intestines (microbiology)
  • Linolenic Acids (administration & dosage)
  • Lipid Metabolism
  • Lipids (blood)
  • Male
  • Nutritive Value
  • Obesity (etiology, metabolism)
  • Plant Oils (administration & dosage)
  • Rapeseed Oil
  • Rats
  • Rats, Wistar
  • Transaminases (blood)
  • Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: