HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and hypoxia inducible gene 2 in hemangioblastomas.

AbstractINTRODUCTION:
Hemangioblastomas occur as sporadic or as von Hippel-Lindau syndrome (VHL) associated tumors. In both settings, activation of the VHL-HIF-1 (hypoxia induced factor) pathway is thought to be important in tumor biology.
MATERIAL AND METHODS:
We performed immunohistochemical studies on 23 hemangioblastomas, 13 meningiomas and 4 hemangiopericytomas to evaluate expression of the VHL-HIF-1 regulated proteins vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX) and hypoxia inducible gene 2 (HIG-2).
RESULTS:
Hemangioblastomas showed significantly higher expression of CAIX and VEGF than the other tested tumors. They showed strong membranous expression of CAIX in a pattern identical to that observed in clear cell renal cell carcinomas (CCRCC). Interestingly, hemangioblastomas lacked significant reactivity for HIG-2.
CONCLUSIONS:
The VHL-HIF-1 regulated genes VEGF and CAIX are expressed in hemangioblastomas but significant HIG-2 expression is not observed. Carbonic anhydrase IX staining in particular may be a helpful marker of hemangioblastomas but does not aid in the distinction from CCRCC.
AuthorsMei Li, Jie Song, Peter Pytel
JournalFolia neuropathologica (Folia Neuropathol) Vol. 52 Issue 3 Pg. 234-42 ( 2014) ISSN: 1509-572X [Electronic] Poland
PMID25310734 (Publication Type: Journal Article)
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • HILPDA protein, human
  • Hypoxia-Inducible Factor 1
  • Neoplasm Proteins
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • CA9 protein, human
  • Carbonic Anhydrase IX
  • Carbonic Anhydrases
Topics
  • Antigens, Neoplasm (analysis, biosynthesis)
  • Biomarkers, Tumor (analysis)
  • Carbonic Anhydrase IX
  • Carbonic Anhydrases (analysis, biosynthesis)
  • Cerebellar Neoplasms (metabolism)
  • Hemangioblastoma (metabolism)
  • Humans
  • Hypoxia-Inducible Factor 1 (genetics, metabolism)
  • Immunohistochemistry
  • Neoplasm Proteins (analysis, biosynthesis)
  • Vascular Endothelial Growth Factor A (analysis, biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: