An overview of various mammalian models to study chronic copper intoxication associated Alzheimer's disease like pathology.

Abstract

Chronic copper toxicity has been long known to cause hepatotoxicity and liver cirrhosis as observed in Wilson's disease; however, substantial evidence accrued over the time have shown considerable increase in animal studies demonstrating Alzheimer's disease like pathology due to chronic copper-intoxication under certain conditions. This review integrates the contemporary mammalian studies in which the effect of chronic copper intoxication was assessed on the central nervous system and cognition of animals.

• Authors: Amit Pal, Rajendra Prasad
• Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (Biometals) Vol. 28 Issue 1 Pg. 1-9 (Feb 2015) ISSN: 1572-8773 [Electronic] Netherlands
• PMID: 25307560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Copper

Topics

• Alzheimer Disease (chemically induced, pathology)
• Animals
• Central Nervous System (metabolism, pathology)
• Cognition (physiology)
• Copper (toxicity)
• Disease Models, Animal
• Mammals
• Neurodegenerative Diseases (chemically induced, pathology)