Abstract | INTRODUCTION: AREAS COVERED: In this review we investigated the molecular alteration present in TNBC which could lead to the creation of new targeted therapies in the future, with the aim to counteract this disease in the most effective way. EXPERT OPINION: In this context some hormone receptors like G-protein-coupled receptor 30 and androgen receptors may be a fascinating area to investigate; also, angiogenesis, represented not only by the classical VEGF/VEGFR relationship, but also by other molecules, like semaphorins, fibroblast growth factor and heparin-binding- EGF-like, is a mechanism in which new developments are expected. In this perspective, one technique that may show promise is the gene therapy; in particular the gene transfer could correct abnormal genetic function in cancer cells.
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Authors | Anselmo Papa, Davide Caruso, Silverio Tomao, Luigi Rossi, Eleonora Zaccarelli, Federica Tomao |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 19
Issue 1
Pg. 55-75
(Jan 2015)
ISSN: 1744-7631 [Electronic] England |
PMID | 25307277
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Animals
- Genes, Tumor Suppressor
- Humans
- Neovascularization, Pathologic
- Oncogenes
- Receptors, Steroid
(metabolism)
- Triple Negative Breast Neoplasms
(drug therapy, genetics, metabolism, pathology)
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