Abstract |
The role of serotonin in the mediation of the anticonvulsant activity of JAW-669 was investigated against maximal electric shock (MES)-induced seizures in mice. A dose-dependent protection against seizures was provided by JAW-669 (4, 6 and 8 mg/kg, IP) and the calculated ED50 value was 6.01 mg/kg, IP. Pretreatment of mice with 5-hydroxytryptophan (50 mg/kg, IP) 2 hr before the administration of JAW-669 (6.01 mg/kg, IP) was found to cause a 40% increase in the ability of JAW-669 to provide protection against MES-induced seizures. Similar pretreatment with tryptophan (100 mg/kg, IP, 1 hr) caused a 30% decrease in the anticonvulsant activity of JAW-669. Prior administration of p-chlorophenylalanine (300 mg/kg, IP, 48 hr) and methysergide (10 mg/kg, IP; 0.5 hr) before administration of JAW-699 caused a 66% and 74% decrease, respectively, in the ability of JAW-669 to provide protection against MES-induced seizures. These results suggest a facilitatory role of serotonin in the anticonvulsant activity of JAW-669.
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Authors | L M Leadbetter, S J Brumleve, J A Waters, S S Parmar |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 46
Issue 1
Pg. 35-7
(Jul 1989)
ISSN: 0031-9384 [Print] United States |
PMID | 2530601
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Biphenyl Compounds
- Propanolamines
- Receptors, Serotonin
- 3-diethylamino-1-propanol 2-phenylbenzoate
- Serotonin
- Tryptophan
- 5-Hydroxytryptophan
- Fenclonine
- Methysergide
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Topics |
- 5-Hydroxytryptophan
(pharmacology)
- Animals
- Anticonvulsants
(pharmacology)
- Biphenyl Compounds
(pharmacology)
- Brain
(drug effects)
- Dose-Response Relationship, Drug
- Electroshock
- Fenclonine
(pharmacology)
- Kindling, Neurologic
(drug effects)
- Male
- Methysergide
(pharmacology)
- Mice
- Mice, Inbred Strains
- Propanolamines
(pharmacology)
- Receptors, Serotonin
(drug effects)
- Serotonin
(physiology)
- Tryptophan
(pharmacology)
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