The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats.

Abstract

Oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Ferulic acid (FA), a well-established natural antioxidant, has several pharmacological activities including anti-inflammatory, anticancer and hepatoprotective. This study aimed to investigate the effects of FA on sepsis-induced oxidative damage in Wistar albino rats. Sepsis-induced DNA damage in the lymphocytes, liver and kidney cells of rats were evaluated by comet assay with and without formamidopyrimidine DNA glycosylase (Fpg). The oxidative stress parameters such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and total glutathione (GSH) and malondialdehyde (MDA) levels were also measured. It is found that DNA damage in sepsis+FA-treated group was significantly lower than the sepsis group. FA treatment also decreased the MDA levels and increased the GSH levels and SOD and GSH-Px activities in the sepsis-induced rats. It seems that FA might have ameliorative effects against sepsis-induced oxidative damage.

• Authors: Merve Bacanlı, Sevtap Aydın, Gökçe Taner, Hatice Gül Göktaş, Tolga Şahin, A Ahmet Başaran, Nurşen Başaran
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 38 Issue 3 Pg. 774-82 (Nov 2014) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 25305738 (Publication Type: Journal Article)
• Copyright: Copyright © 2014. Published by Elsevier B.V.

Chemical References

• Antioxidants
• Coumaric Acids
• Malondialdehyde
• ferulic acid
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione

Topics

• Animals
• Antioxidants (administration & dosage, pharmacology)
• Coumaric Acids (administration & dosage, pharmacology)
• DNA Damage (drug effects)
• Gene Expression Regulation (drug effects)
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Kidney (metabolism)
• Liver (metabolism)
• Lymphocytes (metabolism)
• Malondialdehyde (metabolism)
• Oxidative Stress (drug effects)
• Rats
• Rats, Wistar
• Sepsis (metabolism, pathology)
• Superoxide Dismutase (metabolism)