Ethanolic extract of Taheebo attenuates increase in body weight and fatty liver in mice fed a high-fat diet.

Abstract

We evaluated whether intake of an ethanolic extract of Taheebo (TBE) from Tabebuia avellanedae protects against body weight increase and fat accumulation in mice with high-fat diet (HFD)-induced obesity. Four-week old male C57BL/6 mice were fed a HFD (25% fat, w/w) for 11 weeks. The diet of control (HFD) mice was supplemented with vehicle (0.5% sodium carboxymethyl cellulose by gavage); the diet of experimental (TBE) mice was supplemented with TBE (150 mg/kg body weight/day by gavage). Mice administered TBE had significantly reduced body weight gain, fat accumulation in the liver, and fat pad weight, compared to HFD mice. Reduced hypertrophy of fat cells was also observed in TBE mice. Mice administered TBE also showed significantly lower serum levels of triglycerides, insulin, and leptin. Lipid profiles and levels of mRNAs and proteins related to lipid metabolism were determined in liver and white adipose tissue of the mice. Expression of mRNA and proteins related to lipogenesis were decreased in TBE-administered mice compared to mice fed HFD alone. These results suggest that TBE inhibits obesity and fat accumulation by regulation of gene expression related to lipid metabolism in HFD-induced obesity in mice.

• Authors: Won Hee Choi, Min Young Um, Jiyun Ahn, Chang Hwa Jung, Myung Kyu Park, Tae Youl Ha
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 19 Issue 10 Pg. 16013-23 (Oct 08 2014) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 25299819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Plant Extracts
• Taheebo

Topics

• Adipogenesis (drug effects, genetics)
• Adipose Tissue (drug effects, metabolism)
• Animals
• Body Weight (drug effects)
• Diet, High-Fat (adverse effects)
• Disease Models, Animal
• Fatty Liver (drug therapy, etiology, genetics, metabolism)
• Gene Expression Regulation (drug effects)
• Lipid Metabolism (drug effects)
• Lipogenesis (drug effects, genetics)
• Male
• Mice
• Plant Extracts (pharmacology)