Prognostic significance of complications after laparoscopic colectomy for colon cancer.

Abstract

AIMS:

This study sought to evaluate the prognostic significance of postoperative complications for colon cancer patients undergoing laparoscopic surgery.

METHODS:

From May 2006 to May 2009, a total 224 patients who underwent laparoscopic curative resection (R0) for colon cancer were included in our retrospective study. Postoperative complications were evaluated according to a standardized grading system. The main outcome measurements of our study were overall survival (OS) and relapse-free survival (RFS), which were then compared between the no complication and complication groups. Univariate and multivariate analysis were used to assess the correlation between complications and prognosis.

RESULTS:

Fifty-nine postoperative complications occurred in 43 patients. The overall morbidity rate was 26.3%. The 5-year OS in the complication group was 41.4% compared with 78.5% in the no complication group (P<0.001). The cumulative incidence of relapse was also more aggressive in patients with complications (5-year RFS: complication group 40.9% vs. no complication group 82.1%, P<0.001). Multivariate analysis identified complications as a significant factor increasing the risk for both OS (RR 2.737; 95% CI 1.512-4.952; P = 0.001) and RFS (RR 4.247; 95% CI 2.291-7.876; P<0.001).

CONCLUSION:

Postoperative complications could pose a significant adverse impact not only on OS but also on RFS in patients with colon cancer even when laparoscopic R0 resection is available.

• Authors: Xiang Xia, Weidong Wu, Kundong Zhang, Gang Cen, Tao Jiang, Jun Cao, Kejian Huang, Chen Huang, Zhengjun Qiu
• Journal: PloS one (PLoS One) Vol. 9 Issue 10 Pg. e108348 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 25299478 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Colectomy (adverse effects)
• Colonic Neoplasms (diagnosis, pathology, surgery)
• Female
• Humans
• Laparoscopy (adverse effects)
• Male
• Neoplasm Recurrence, Local (etiology)
• Postoperative Complications
• Prognosis
• Retrospective Studies
• Treatment Outcome