Abstract | BACKGROUND: The fruit of Kochia scoparia Scharder is widely used as a medicinal ingredient for the treatment of dysuria and skin diseases in China, Japan and Korea. Especially, K. scoparia had been used for breast masses and chest and flank pain. OBJECTIVE: MATERIALS AND METHODS: RESULTS: MTT assay results demonstrated that MEKS decreased the proliferation rates of MDA-MB-231 cells in a dose-dependent manner with an IC50 value of 36.2 μg/ml. MEKS at 25 μg/ml significantly increased the sub-G1 DNA contents of MDA-MB-231 cells to 44.7%, versus untreated cells. In addition, MEKS induced apoptosis by increasing the levels of apoptosis-associated proteins such as cleaved caspase 3, cleaved caspase 8, cleaved caspase 9 and cleaved Poly (ADP-ribose) polymerase (PARP). CONCLUSION: These results suggest that MEKS inhibits cell proliferation and induces apoptosis in breast cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human breast cancer.
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Authors | Hye-Yeon Han, Hyungwoo Kim, Yong Hae Son, Guemsan Lee, Sung-Hee Jeong, Mi Heon Ryu |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
Vol. 10
Issue Suppl 3
Pg. S661-7
(Aug 2014)
ISSN: 0973-1296 [Print] India |
PMID | 25298688
(Publication Type: Journal Article)
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