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Toxicity induced by F. poae-contaminated feed and the protective effect of Montmorillonite supplementation in broilers.

Abstract
The T-2 and HT-2 toxins, the main metabolites of Fusarium poae, induce toxicity in broilers and accumulate in tissues. Consequently, during the breeding process of broilers, diets are frequently supplemented with physical adsorbents to protect birds against the toxicity induced by mycotoxins. In the present research, T-2 and HT-2 were produced in maize inoculated with F. poae. Mont, the strongest adsorbent based on in vitro adsorption ratios, was added to the contaminated diet. One-day-old chickens were randomly and equally divided into the following four groups: control diet group, Mont supplemented diet group, contaminated diet group and detoxification diet group. The experiment lasted for 42 days. Compared to the control group, the contaminated group showed significant decrease in body weight, feed intake and TP (P < 0.05), and marked increase in FCR, ALP, AST and ALT activity, T-2/HT-2 residues in the tissues and the relative expressions of apoptosis-related mRNAs (P < 0.05). Mont supplementation provided protection for the treated broilers in terms of performance, blood biochemistry, hepatic function, T-2/HT-2 residue of tissues and apoptosis. Therefore, Mont may be suitable as a detoxification agent for T-2/HT-2 in feed for broilers.
AuthorsLingchen Yang, Zhiyong Zhao, Yifeng Deng, Zhenlei Zhou, Jiafa Hou
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 74 Pg. 120-30 (Dec 2014) ISSN: 1873-6351 [Electronic] England
PMID25296281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Bentonite
  • T-2 Toxin
  • HT-2 toxin
Topics
  • Animal Feed (microbiology, toxicity)
  • Animals
  • Bentonite (pharmacology)
  • Chickens
  • Dietary Supplements
  • Female
  • Food Contamination
  • Fusarium
  • Male
  • T-2 Toxin (analogs & derivatives, antagonists & inhibitors, toxicity)
  • Zea mays (microbiology)

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