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Thioridazine for treatment of tuberculosis: promises and pitfalls.

Abstract
The articles by De Knegt et al. and Singh et al. in a recent issue of this Journal address one of the current debates regarding the potential role of thioridazine in the treatment of tuberculosis. This commentary presents a summary of the available evidence, and, emphasizing the need for further research, asks the question: "How far can we go in repurposing thioridazine?"
AuthorsNoton K Dutta, Petros C Karakousis
JournalTuberculosis (Edinburgh, Scotland) (Tuberculosis (Edinb)) Vol. 94 Issue 6 Pg. 708-11 (Dec 2014) ISSN: 1873-281X [Electronic] Scotland
PMID25293998 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Comment)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Antitubercular Agents
  • Pyrazinamide
  • Thioridazine
  • Isoniazid
  • Rifampin
Topics
  • Animals
  • Antitubercular Agents (pharmacology)
  • Female
  • Isoniazid (pharmacology)
  • Mycobacterium tuberculosis (drug effects)
  • Pyrazinamide (pharmacology)
  • Rifampin (pharmacology)
  • Thioridazine (pharmacology)
  • Tuberculosis (drug therapy)

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