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Low CSF met-enkephalin levels in cluster headache are elevated by acupuncture.

Abstract
Significantly lower met-enkephalin levels were found in CSF from cluster headache sufferers as compared to age-matched healthy volunteers, whereas it was not possible to demonstrate any clear-cut difference for beta-endorphin. CSF opioid levels may rise following manual or electroacupuncture. It was studied whether traditional Chinese (manual) acupuncture affected CSF levels of met-enkephalin or beta-endorphin in these patients, and to what extent this treatment would be beneficial for the headache. A significant rise in lumbar CSF met-enkephalin levels was found, whereas no clear change in beta-endorphin levels was obtained. The treatment was, however, of little value in preventing the headache.
AuthorsJ E Hardebo, R Ekman, M Eriksson
JournalHeadache (Headache) Vol. 29 Issue 8 Pg. 494-7 (Sep 1989) ISSN: 0017-8748 [Print] United States
PMID2529227 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Enkephalin, Methionine
  • beta-Endorphin
Topics
  • Acupuncture Therapy
  • Adult
  • Aged
  • Cluster Headache (cerebrospinal fluid, therapy)
  • Enkephalin, Methionine (cerebrospinal fluid)
  • Humans
  • Male
  • Middle Aged
  • Vascular Headaches (cerebrospinal fluid)
  • beta-Endorphin (cerebrospinal fluid)

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