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Pericentrin: critical for spindle orientation.

Abstract
Mutations in the pericentrin (PCNT) gene cause Majewski osteodysplastic primordial dwarfism type II (MOPDII). Recent work reveals that a discrete set of centrosome proteins require PCNT for their robust localization to mitotic spindle poles. Critically, this complex is crucial for mitotic spindle orientation and involved in the pathogenesis of MOPDII.
AuthorsYi Luo, Laurence Pelletier
JournalCurrent biology : CB (Curr Biol) Vol. 24 Issue 19 Pg. R962-4 (Oct 06 2014) ISSN: 1879-0445 [Electronic] England
PMID25291638 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Antigens
  • pericentrin
Topics
  • Animals
  • Antigens (genetics)
  • Dwarfism (genetics)
  • Fetal Growth Retardation (genetics)
  • Humans
  • Microcephaly (genetics)
  • Microtubules (genetics)
  • Mitosis
  • Osteochondrodysplasias (genetics)
  • Spindle Apparatus (genetics)

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