Abstract |
An HLA-DR product encoded by the HLA-DRw13/Dw19 haplotype has been identified as the HLA class II molecule involved in antigen presentation to several influenza-specific helper T cell clones. Three different functional sites were identified on this molecule by comparing the structure of HLA-DR products of known sequences and their ability to efficiently present foreign antigen to the T cell clones. These functional sites were mapped on the recently proposed three-dimensional structure of HLA class II molecules. From their position, these sites are all potentially involved in HLA- peptide interaction and capable of affecting the binding and/or the conformation of the foreign peptide. This suggests that polymorphic residues essential in major histocompatibility complex restriction are mostly involved in peptide binding.
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Authors | G Sterkers, J M Tiercy, D Zeliszewski, J P Levy, B Mach |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 19
Issue 9
Pg. 1585-90
(Sep 1989)
ISSN: 0014-2980 [Print] Germany |
PMID | 2529124
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Viral
- HLA-DR Antigens
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Topics |
- Amino Acid Sequence
- Antigen-Presenting Cells
(immunology)
- Antigens, Viral
(immunology)
- Clone Cells
- HLA-DR Antigens
(immunology)
- Haplotypes
- Humans
- In Vitro Techniques
- Influenza A virus
(immunology)
- Molecular Sequence Data
- Protein Conformation
- Structure-Activity Relationship
- T-Lymphocytes, Helper-Inducer
(immunology)
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