Abstract | BACKGROUND: METHODS: The study design was a systematic review. We selected studies with adequate information to ascertain test sensitivity or specificity of the TST, QFT-G, and TSPOT.TB with regards to determining latent tuberculosis infection in the hemodialysis population. RESULTS: One hundred two articles were selected for full review, and 17 were included in the meta-analysis. The TST had a pooled sensitivity of 31% (26%-36%, 95% confidence interval) and specificity of 63% (60%-65%) across eight studies. The QFT-G test had a pooled sensitivity of 53% (46%-59%) and specificity of 69% (65%-72%) across nine studies. The T-SPOT.TB test had a pooled sensitivity of 50% (42%-59%) and specificity of 67% (61%-73%) across three studies. CONCLUSION: The QFT-G and the T-SPOT.TB tests were more sensitive than the TST for diagnosis of latent tuberculosis infection in patients on hemodialysis while offering a comparable level of specificity. This systematic review calls into question the practice of using the TST to screen in this population, especially in patients considered for kidney transplantation.
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Authors | Thomas W Ferguson, Navdeep Tangri, Kerry Macdonald, Brett Hiebert, Claudio Rigatto, Manish M Sood, Souradet Shaw, Blake Lerner, Yang Xu, Salaheddin Mahmud, Paul Komenda |
Journal | Transplantation
(Transplantation)
Vol. 99
Issue 5
Pg. 1084-91
(May 2015)
ISSN: 1534-6080 [Electronic] United States |
PMID | 25286055
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Topics |
- Humans
- Latent Tuberculosis
(diagnosis)
- Renal Dialysis
(adverse effects)
- Sensitivity and Specificity
- Tuberculin Test
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