Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai children with arterial ischemic stroke.

Abstract

BACKGROUND:

Prolonged euglobulin clot lysis time (ECLT) and increased level of plasminogen activator inhibitor-1 (PAI-1) were reported to be risk factors of arterial ischemic stroke (AIS) by some studies; however, these findings were not supported by other studies. The objective of this study was to determine the association of ECLT, PAI-1 level, and polymorphisms of 4G and 5G of PAI-1 gene to the development of AIS in Thai children.

METHODS:

This study included patients aged 1-18 years old. Diagnosis of AIS was confirmed by imaging study. The control group was age- and sex-matched healthy subjects. Demographic data were recorded, and blood was tested for ECLT, PAI-1 level, lipid profiles, fasting blood sugar (FBS), and 4G and 5G polymorphisms of PAI-1 gene.

RESULTS:

There were 70 subjects participating in this study, consisting of 30 patients and 40 controls. Demographic data, lipid profiles, and FBS were similar between the 2 groups. Furthermore, ECLT and PAI-1 level did not differ between patient and control groups; however, both showed significant correlation (r = .352, P = .006). The 4G/5G polymorphism was the most common genotype in both patient and control groups (69.0% vs. 80.0%). However, 4G and 5G polymorphisms of PAI-1 gene did not correlate with PAI-1 level in this study (P = .797).

CONCLUSIONS:

The PAI-1 level and 4G/5G polymorphism may not be a risk factor of AIS in this population. It was also found that the 4G/5G polymorphism was the most common PAI-1 genotype in this study.

• Authors: Rungrote Natesirinilkul, Werasak Sasanakul, Ampaiwan Chuansumrit, Praguywan Kadegasem, Anannit Visudtibhan, Pakawan Wongwerawattanakoon, Nongnuch Sirachainan
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) 2014 Nov-Dec Vol. 23 Issue 10 Pg. 2566-2572 ISSN: 1532-8511 [Electronic] United States
• PMID: 25284719 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Lipids
• Plasminogen Activator Inhibitor 1
• Fibrinogen

Topics

• Adolescent
• Asian People (genetics)
• Blood Glucose (analysis)
• Brain Ischemia (blood, genetics)
• Case-Control Studies
• Child
• Child, Preschool
• Fasting (blood)
• Female
• Fibrinogen (analysis)
• Fibrinolysis (genetics)
• Genetic Predisposition to Disease
• Humans
• Infant
• Lipids (blood)
• Male
• Plasminogen Activator Inhibitor 1 (blood, genetics)
• Polymorphism, Genetic
• Risk Factors
• Stroke (blood, genetics)