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[Induction of differentiation of human promyelocytic leukemia (HL-60) cells by new retinoid R-81001].

Abstract
By using soft agar colony-forming assay, a monoclonal subline of human promyelocytic leukemia HL-60 cells was isolated and inducing activity of differentiation of a new retinoid R-81001 on the cells was studied. Phenotypic changes, such as biologic behavior, morphological and biochemical characteristics, show that R-81001 can induce HL-60 cells to differentiate along the myeloid pathway.
AuthorsL Jiao
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 11 Issue 2 Pg. 102-6 (Apr 1989) ISSN: 1000-503X [Print] China
PMID2528415 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Tretinoin
  • N-(4-aminosulfonylphenyl)retinamide
Topics
  • Antineoplastic Agents (pharmacology)
  • Cell Differentiation (drug effects)
  • Humans
  • Leukemia, Promyelocytic, Acute (pathology)
  • Tretinoin (analogs & derivatives, pharmacology)
  • Tumor Cells, Cultured (drug effects)

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