Abstract |
By using soft agar colony-forming assay, a monoclonal subline of human promyelocytic leukemia HL-60 cells was isolated and inducing activity of differentiation of a new retinoid R-81001 on the cells was studied. Phenotypic changes, such as biologic behavior, morphological and biochemical characteristics, show that R-81001 can induce HL-60 cells to differentiate along the myeloid pathway.
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Authors | L Jiao |
Journal | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
(Zhongguo Yi Xue Ke Xue Yuan Xue Bao)
Vol. 11
Issue 2
Pg. 102-6
(Apr 1989)
ISSN: 1000-503X [Print] China |
PMID | 2528415
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Tretinoin
- N-(4-aminosulfonylphenyl)retinamide
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Topics |
- Antineoplastic Agents
(pharmacology)
- Cell Differentiation
(drug effects)
- Humans
- Leukemia, Promyelocytic, Acute
(pathology)
- Tretinoin
(analogs & derivatives, pharmacology)
- Tumor Cells, Cultured
(drug effects)
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