Effects in vivo and in vitro of benthiocarb on developing rat (Wistar strain) brain Mg2+ and Ca2+-ATPases.

Abstract

Effects in vivo and in vitro of benthiocarb on developing rat brain Mg2+ and Ca2+-ATPases have been studied. Decreased activities of Mg2+ and Ca2+-ATPases suggests impairment in energy synthesis and utilization processes in developing CNS of rat during benthiocarb poisoning. Effects in vitro of benthiocarb on these enzymes revealed that Km (Michaelis-Menten Constant) of both the enzymes increased whereas Vmax (Maximal velocity) decreased significantly indicating mixed type of inhibition on these enzymes by benthiocarb.

• Authors: P N Srinivas, G R Reddy, C S Chetty
• Journal: Biochemistry international (Biochem Int) Vol. 19 Issue 1 Pg. 145-53 (Jul 1989) ISSN: 0158-5231 [Print] Australia
• PMID: 2528350 (Publication Type: Journal Article)

Chemical References

• Thiocarbamates
• Adenosine Triphosphate
• benthiocarb
• Ca(2+) Mg(2+)-ATPase
• Calcium-Transporting ATPases
• Calcium

Topics

• Adenosine Triphosphate (metabolism)
• Animals
• Binding Sites
• Brain (enzymology, growth & development)
• Ca(2+) Mg(2+)-ATPase (antagonists & inhibitors, metabolism)
• Calcium (metabolism)
• Calcium-Transporting ATPases (antagonists & inhibitors, metabolism)
• Cell Membrane (enzymology)
• Kinetics
• Rats
• Rats, Inbred Strains
• Thiocarbamates (pharmacology, toxicity)