Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.

Dementia and brain atrophy are established features of a large proportion of patients with acquired immune deficiency syndrome (AIDS). To investigate a potential mechanism for atrophy in AIDS, we measured the concentration of the endogenous neurotoxin quinolinic acid in the cerebrospinal fluid of 10 patients with AIDS and found that they had 3-fold higher quinolinic acid concentrations than 9 age-matched control subjects: 53.8 +/- 10.7 pmol/ml versus 18.4 +/- 3.4 pmol/ml, respectively (p less than 0.005). It remains to be determined whether increased brain quinolinic acid concentrations are involved in the pathogenesis of the neuropathology of AIDS.
AuthorsM P Heyes, D Rubinow, C Lane, S P Markey
JournalAnnals of neurology (Ann Neurol) Vol. 26 Issue 2 Pg. 275-7 (Aug 1989) ISSN: 0364-5134 [Print] UNITED STATES
PMID2528321 (Publication Type: Journal Article)
Chemical References
  • Pyridines
  • Quinolinic Acids
  • Tryptophan
  • Quinolinic Acid
  • Acquired Immunodeficiency Syndrome (cerebrospinal fluid)
  • Adult
  • Female
  • Humans
  • Male
  • Pyridines (cerebrospinal fluid)
  • Quinolinic Acid
  • Quinolinic Acids (cerebrospinal fluid)
  • Tryptophan (metabolism)

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