Prothrombin complex concentrate (Beriplex P/N)-related renal and cerebral infarctions in a patient with warfarin-associated intracerebral hemorrhage.

Abstract

A 45-year-old man receiving warfarin treatment suffered from an intracerebral hemorrhage. Four-factor prothrombin complex concentrate (PCC) was administered to correct coagulopathy. However, bilateral renal infarcts and a cerebral infarct developed on day 5 and 7, respectively after PCC administration. Although the occurrence of PCC-related thromboembolism is low, health care practitioners should closely follow-up the symptoms and signs of thrombosis after PCC administration.

• Authors: Shin-Yi Lin, Sun-Chun Tang, Li-Jiuan Shen, Jiann-Shing Jeng
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 24 Issue 1 Pg. e15-6 (Jan 2015) ISSN: 1532-8511 [Electronic] United States
• PMID: 25282184 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anticoagulants
• Drug Combinations
• factor IX, factor VII, factor X, prothrombin drug combination
• Warfarin
• Factor VII
• Prothrombin
• Factor IX
• Factor X

Topics

• Anticoagulants (adverse effects, therapeutic use)
• Cerebral Hemorrhage (chemically induced, drug therapy)
• Cerebral Infarction (chemically induced)
• Drug Combinations
• Factor IX (adverse effects, therapeutic use)
• Factor VII (adverse effects, therapeutic use)
• Factor X (adverse effects, therapeutic use)
• Humans
• Infarction (chemically induced)
• Kidney (blood supply)
• Male
• Middle Aged
• Prothrombin (adverse effects, therapeutic use)
• Warfarin (adverse effects, therapeutic use)